What is the evidence for radiation for Dupuytren’s contracture?
AMSTAR Rating
Summary
Patient Population:
- Patients with Dupuytren’s contracture
- 1 randomized controlled trial and 5 retrospective cohort studies
- The mean age of participants was 58.5 years. The ratio of males to females was 1.6:1.
Intervention:
- Radiotherapy (total dose range between 21 Gy to <42 Gy)
Comparison:
- Studies either did not have a comparison group or had a comparison group with a different radiation dose.
Outcome:
Disease regression (reduction in number and consistency of cords or nodules, and reduction in extension deficit).
- Three studies reported this outcome [1-3], with a range of 0-56%.
Disease stability (neither regression or progression of disease).
- Three studies reported this outcome [1-3], with a range of 37-98%.
Disease progression.
- Three studies reported this outcome [1-3], with a range of 2-20%.
Proportion of patients requiring surgery following disease progression after radiotherapy
- 3.1-10%.
Symptomatic improvement:
- ranged between 66-87% following radiotherapy.
Complications
- Erythema, skin dryness, and desquamation occurred in 20-43%.
- No study reported radiotherapy-induced malignancy.
Guideline Recommendations
| Source | Recommendation |
|---|---|
| NICE | Current evidence on its efficacy is inadequate |
Outcomes Assessed
- Benefit
- Harm
- Inconclusive
Contracture Reduction
Radiotherapy
Relevant Clinical Info
Overall lack of high quality studies, limits applicability of results to larger populations. Also see EBM reviews of Fasciectomy and Collagenase Injection.
Participant Information
of participants
Male
of participants
Female
their were 698 people.
the sample size was 770 hands
Mean age of 58.5 years.
their were 6 studies used.
