What is the evidence for IV Ketamine infusion for complex regional pain syndrome?
AMSTAR Rating
Summary
Patient Population:
15 studies (only 1 RCT), 258 subjects with CRPS
Mean Age: 37 year old; Mean Duration of CRPS: 40 months
Intervention:
IV Ketamine Infusion (Heterogeneity of study doses), Mean treatment duration was 8.41 days (range 1 to 43.8 days)
Comparison:
Usual care in 1 RCT, Pre- and post- infusion pain scores compared
Outcome:
Immediate pain relief with IV infusion (30% of greater relief on 10-point pain scale)(9 pooled studies)
- 69% (95% CI = 53-84%)
Pain relief at 1-3 months post IV infusion (30% of greater relief on 10-point pain scale)(7 pooled studies)
- 58% (95% CI = 41-75%)
Guideline Recommendations
Outcomes Assessed
- Benefit
- Harm
- Inconclusive
Pain Relief (LOW QUALITY EVIDENCE)
Immediate
1-3 months
> 3 months
Relevant Clinical Info
Low quality evidence (Cohort studies) with varying study and treatment methodologies
Participant Information
the sample size was 258
Mean age of 37 years.
their were 15 studies used.
